Pseudogout, a type of joint disease characterized by inflammation of the joints and can lead to arthritis. Deposition of calcium pyrophosphate dihydrate crystals in and around the joints causes inflammation and results in pseudogout. Is called pseudogout also pyrophosphate arthropathy. Meaning of "pseudogout", the term is false gout. That's because pseudogout resemble gout in many respects, such a disease involving the formation of crystals in the joints and can both lead to arthritis.
However, the difference between the two is the type of crystals. Gout involving the formation of monosodium urate crystals, while the pseudo gout involves the formation of crystals of calcium pyrophosphate dihydrate. It is reported that gout and pseudogout coexist with each other, the two types of crystals are present in joint fluid. Pseudogout affecting men and women equally and is seen often affects the elderly. Approximately 50% of people over 85 years are considered affected by pseudogout.
Causes pseudogout
Collection calcium pyrophosphate dihydrate crystals (PRC) in the fluid around the joints and subsequent formation of CPPD crystals in joints results in inflammation of the joints. Knees, wrists, ankles and other joints are swollen and hurt badly. Exactly why these crystals are formed CPPD is not yet known. However, some believe that in old age, the synovial fluid of joints become more susceptible to CPPD crystal growth.
Pseudogout is really should be hereditary. People suffering from other diseases such as hyperparathyroidism, hemochromatosis, and hypomagnesemia may develop pseudogout. However, it was observed that most people with this disease do not suffer from any of the conditions mentioned above. Although the disease primarily affects the elderly, is also seen to affect young people suffering from diseases such as Wilson disease, thyroid disease, ochronosis, acromegaly, hemochromatosis, or parathyroid disease.
Symptoms of pseudogout
Pseudogout symptoms vary from person to person. Some people are regarded as being affected by painful inflammation of the joints, especially in the wrists, knees, hips and other major joints, while others may have a rigidity and persistence of chronic pain in the arms and legs. Pseudogout attacks can sometimes fever. Then there are people who have no pain between attacks and those who do not have any pain at any time, even with large deposits of crystals. Pseudogout is often misdiagnosed as arthritis, gout, osteoarthritis and rheumatoid arthritis because of the similarity of symptoms.
Like gout, pseudogout, also, the patient suffers from severe joint pain due to swollen joints and red. However, pseudogout usually begins in a village, and then little by little inflammation occurs in several joints. In addition, pseudogout affecting large joints (shoulders, knees, wrists and hips), while gout affects the small joints. In addition, joints are affected by pseudogout of calcified cartilage (chondrocalcinosis). Calcification of cartilage is not seen in the drop. CPPD in pseudogout crystals are formed round while monosodium urate crystals in gout are needle-shaped or spindle.
Treatment of pseudogout
ice packs are applied to reduce pain and inflammation. High doses of colchicine, a drug commonly used in gout, is prescribed to inhibit migration of cells called granulocytes. Granulocytes are white blood cells that are responsible for initiating inflammation of the joints. non-steroidal drugs anti-inflammatory drugs (NSAIDs) such as indomethacin are used to reduce pain and inflammation. Small doses of NSAIDs are administered to prevent recurrence of pseudo-gout. Aspiration of synovial fluid in joints affected is another treatment option that is seen to shorten the attack. To relieve acute joint inflammation, steroids are sometimes injected directly. Currently, there is no available treatment or therapy to suppress CPPD crystals in joints. However, research on surgical removal of the calcification is in progress.
Although treatment to stop acute attacks, they can not repair damage already caused to the joints. Although there is no specific treatment available for long term pseudogout, may follow a physical therapy to strengthen muscles. Range of motion exercises help maintain joint function.
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